The Kozhikode - Mysore National Highway 212 (NH 212) passes through Wayanad district. The nearest railway station is at Kozhikode, 75 km from Kalpetta. Kozhikode airport at Karipur is the nearest airport. Wayanad is well connected by road to various parts of Kerala and other neighbouring states. Buses go frequently between important centres. While travelling from Mysore on NH 212, at a place called Gundulpet the road forks, one goes to Ooty and the other goes to Sultan Batheri, which is a prominent town of Wayanad.

NH 212 passes through Bandipur National Park and then through the Muthanga Wildlife Sanctuary which is the Kerala state border.